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The Four Pillars of HFrEF: Where Does ARNI Fit?

Cardiology - Heart Failure

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This infographic highlights the four foundational pillars of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF), with a focus on the role of angiotensin receptor–neprilysin inhibitors (ARNIs). It explains the complementary mechanisms of ARNI, β-blockers, mineralocorticoid receptor antagonists, and SGLT2 inhibitors, emphasizing the importance of early initiation and optimization of all four therapies to reduce cardiovascular mortality, prevent heart failure hospitalizations, improve symptoms, and enhance long-term patient outcomes.


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HF Frontier

The future of heart failure management lies in translating emerging evidence into everyday clinical practice. HF Frontier is a dedicated scientific forum that brings together contemporary research, guideline-driven recommendations, and expert insights to empower healthcare professionals to deliver optimal heart failure care.

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